Tumor Necrosis Factor Decreases Vitamin D Dependant Calcium Absorption
Status:
Completed
Trial end date:
2009-11-01
Target enrollment:
Participant gender:
Summary
This study is a pilot study to determine whether patients with TNFα excess have decreased
calcium absorption in response to calcitriol (1,25-dihydroxyvitamin D, the active form of
vitamin D) compared to normal controls. This initial pilot study is being done to determine
if it is feasible to conduct a study where TNFα could be blocked (e.g., by anti-TNFα therapy
such as Enbrel® or Remicade®) to improve vitamin D dependant calcium absorption and thus bone
health.
Phase:
N/A
Details
Lead Sponsor:
Atlanta VA Medical Center
Collaborator:
Emory University
Treatments:
Calcitriol Calcium, Dietary Ergocalciferols Vitamin D Vitamins