High values of cardiac troponin (Ct) in acute heart failure (ADHF) identify patients (pts) at
higher risk and worsened prognosis. A Ct increase during therapy indicates the need for more
appropriate intervention, aimed at compensating cardiac disease and effectively minimizing
myocardial wall stress and subsequent cytolysis. This study evaluated the effects of an
intravenous high-dose of furosemide with or without small-volume hypertonic saline solution
(HSS)on myocardial cytolysis in ADHF pts.