Tropisetron on Postoperative Pain

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: Female

Summary

The role of 5-HT3A receptors in nociceptive processing has been demonstrated in several animal models. However, studies in human volunteers have not been reported except for one recent study suggesting that ondansetron could alleviate propofol-induced nociception. Previous studies demonstrated that patients anaesthetized with sevoflurane have more pain than those anaesthetized with propofol. And we further posit that the difference is due to the nociceptive processing induced by the action of 5-HT3A receptors.

In this prospective, randomized, double-blind, placebo-controlled study, we assessed the analgesic action of a 5-HT3A receptor antagonist (tropisetron) in women after gynaecological laparoscopy under general anaesthesia maintained with either sevoflurane or propofol.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Huazhong University of Science and Technology
• Treatments: Anesthetics; Propofol; Tropisetron

Criteria

Inclusion Criteria:

• female patients

• American Society of Anaesthesiologists Physical Status (ASA-PS) I or II

• undergoing selective gynaecological laparoscopies for infertilities

Exclusion Criteria:

• aged under 18 years old

• body mass index (BMI) > 30

• history of cardiovascular disease

• history of respiratory disease

• history of neurologic disease

• history of chronic antidepressants

• history of anxiolytics

• history of chronic analgesics intake

• participating in other studies