Tripterygium Wilfordii Hook F (TwHF) Treatment for Immune Non-responders With HIV-1 Infection
Status:
Unknown status
Trial end date:
2016-12-01
Target enrollment:
Participant gender:
Summary
HIV-1 infection is characterized by progressive depletion of CD4+ T cells that eventually
leads to clinically significant immunodeficiency. A chronic generalized immune activation is
now being recognized to be the main driving force for T cell depletion, loss of anti-HIV-1
immunity and disease progression during chronic HIV-1 infection. However, it is still unknown
whether reducing immune activation will restore CD4 T cell counts and leading to immune
reconstitution in chronic HIV infection. Tripterygium Wilfordii Hook F (TwHF) has been
demonstrated to decrease immune activation of the host, and can suppress inflammation in
human diseases. Here, the investigators propose a hypothesis that TwHF can reduce immune
over-activation which subsequently leads to the restoration of CD4 T-cell counts and immune
reconstitution in HIV-infected immune non-responders.