Triple Combinations Against Hookworm Infections in Lao
Status:
Completed
Trial end date:
2017-12-01
Target enrollment:
Participant gender:
Summary
More than one billion people are infected with soil-transmitted helminths (STH, A.
lumbricoides, hookworm or Trichuris trichiura). Preventive chemotherapy - i.e. annual or
biannual treatment of at-risk populations with albendazole or mebendazole is the current
strategy against STH. However, the efficacy of both drugs is only moderate against hookworm
and low against T. trichiura. For increasing the efficacy and to avoid drug resistance, new
drugs or the combination of different drugs is the way forward.
In this randomised controlled trial, we assess the efficacy (based on cure rates) of
different drug combinations in school-aged children in Lao. 420 hookworm positive children
will be treated: 140 with albendazole-oxantel pamoate, 140 with albendazole-pyrantel
pamoate-oxantel pamoate treatment arms, 70 with pyrantel pamoate-oxantel pamoate and 70 with
mebendazole-pyrantel pamoate-oxantel pamoate. Two stool samples will be collected at baseline
and follow-up (14-21 days after treatment) and analysed with Kato-Katz.