Trichuris Suis Ova (TSO)in Recurrent Remittent Multiple Sclerosis and Clinically Isolated Syndrome
Status:
Terminated
Trial end date:
2017-06-01
Target enrollment:
Participant gender:
Summary
Trichuris suis ova (TSO) is a probiotic treatment based on the hygiene hypothesis, that has
proven safe and effective in autoimmune inflammatory bowel disease. Clinical trails indicate
that helminth infections have an immunomodulatory effect in multiple sclerosis as well.
Investigators hypothesize that TSO® 2500 eggs given oral every 2 weeks for 12 months is - due
to its immunomodulatory and antiinflammatory effect - in recurrent remittent multiple
sclerosis and clinically isolated syndrome significantly more effective than an oral placebo
treatment as assed by new T2 lesions in cerebral magnetic resonance imaging and clinical
examination.