Trichloroacetic Acid as a Topical Treatment for Actinic Cheilitis
Status:
Recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Actinic cheilitis is a condition of the lower lip characterized by grayish-white areas of
discoloration and blunting of the demarcation between the cutaneous lip and the mucosa.
While many studies have compared treatment options for actinic cheilitis, there is still
significant debate over how to best manage this condition. The chosen treatment regimen must
result in complete remission while also preventing recurrence and malignant transformation.
Current treatment options are vast, including both non-surgical and surgical options. Common
topical therapies include 5-fluorouracil, imiquimod, ingenol mebutate and diclofenac. More
recently, photodynamic therapy has been brought forward as a potential treatment modality.
From a surgical perspective, a vermilionectomy is typically the procedure of choice.
TCA is a popular topical treatment for treat fine rhytides, hyperpigmentation, photodamage,
and premalignant changes, such as actinic keratoses. Despite this, TCA is not commonly used
for actinic changes on the lips. Here, the investigators propose an expansion of the
application of TCA to be used in the treatment of actinic cheilitis.