Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children
Status:
Completed
Trial end date:
2016-08-01
Target enrollment:
Participant gender:
Summary
Atopic dermatitis (AD) is an immune disorder, characterized by chronic skin inflammation or
relapsing, whose prevalence is increasing worldwide. Its exact etiology remains unknown. The
hypothesis that an appropriate early stimulation of the intestinal flora contributes to the
establishment of the immune system balance has led to the use of probiotics in the prevention
and treatment of AD in several clinical and experimental studies.
Therefore, the objectives of this study will evaluate the clinical efficacy of the mixture of
probiotics (Lactobacillus and Bifidobacterium) in children with AD through the SCORAD
(scoring atopic dermatitis) and to evaluate the effects of this medication in the following
laboratory parameters: skin prick test, total serum immunoglobulin E (IgE), inflammation
composite (interferon gamma [ɣ - IFN], interleukins [IL1-β, IL-4, IL-6, IL-8] and tumor
necrosis factor alpha) and immune tolerance composite (IL-10, IL-17 and transforming growth
factor beta [TGF - β]).