Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission
Status:
Completed
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
Giving anti-HIV medications to babies born of HIV positive mothers right after birth can
lower the babies' risk of contracting HIV. This study will assess the safety and efficacy of
two different combinations of anti-HIV medications compared to a one drug standard regimen in
preventing mother to baby transmission. The one drug standard treatment and two combinations
to be studied are: 1) zidovudine, 2) zidovudine/nevirapine and 3)
zidovudine/lamivudine/nelfinavir.
Phase:
Phase 3
Details
Lead Sponsor:
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator:
National Institute of Allergy and Infectious Diseases (NIAID)