Trial of Sertraline Versus Cognitive Behaviour Therapy for Generalised Anxiety
Status:
Terminated
Trial end date:
2016-02-01
Target enrollment:
Participant gender:
Summary
Generalised Anxiety Disorder (GAD) is common, causes unpleasant symptoms and impairs people's
functioning. It is often chronic and may be accompanied by depression and other anxiety
disorders. It is not currently clear whether medication or psychological therapy provides
better long term outcomes for those not responding to simpler low intensity treatments so we
propose to compare the clinical effectiveness of a pharmacological treatment (the drug
Sertraline) with a Cognitive Behavioural Therapy (CBT) intervention.
Our hypothesis is that in people with GAD who have not responded to low intensity
psychological interventions, CBT will lead to a greater improvement in their GAD symptoms as
measured using the GAD-7 scale at 12 month follow-up than Sertraline.
Phase:
Phase 4
Details
Lead Sponsor:
University College, London
Collaborators:
National Institute for Health Research, United Kingdom NHS Health Technology Assessment Programme