Trial of Randomized Antibiotic Administration in Percutaneous Nephrolithotomy

• Status: Unknown status
• Trial end date: 2019-07-01
• Target enrollment: 0
• Participant gender: All

Summary

The Investigators objective is to compare the clinical efficacy of a single-day protocol with a short-course protocol for PCNL. The investigator hope is to reduce the use of possibly unnecessary prolonged antibiotic use, reduce hospital costs and prevent the further propagation of resistant microbes.

• Phase: Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Northwell Health
• Treatments: Anti-Bacterial Agents; Antibiotics, Antitubercular; Cephalosporins; Clindamycin; Clindamycin palmitate; Clindamycin phosphate; Fluoroquinolones; Metronidazole; Sulbactam

Criteria

Inclusion Criteria:

• Patients >18 years old

• Negative urine culture within 1 month prior to procedure

• Renal Calculi which would optimally require PCNL for treatment.

Exclusion Criteria:

• Patients <18 years old.

• Patients who are not able to give consent for study

• Patients currently on antibiotics immediately prior to the procedure

• Previous history of sepsis or SIRS from stone manipulations

• Foley catheter in place for greater than 1 week duration

• Patients under going planned, multi-staged procedures

• Immunosuppressed patients