Trial of Proton Pump Inhibitor With Prokinetics or Placebo in Patients With Laryngopharyngeal Reflux Disease
Status:
Unknown status
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
Based on meta-analysis of prokinetics trials in laryngopharyngeal reflux disease (LPRD)
(Glicksman et al. 2014), well designed study was performed in 4 articles. But, those studies
had several problems including inclusion criteria, randomization methods, and placebo
medication. They had similar results that prokinetics and proton pump inhibitor (PPI) had
synergistic effect for management of LPRD. Therefore, the aim of study is to evaluate the
efficacy of prokinetics as an additional medication to proton pump inhibitor by well designed
randomized double blind case-control study.