Trial of Oral Versus Intravenous Proton Pump Inhibitor on Intragastric pH in Patients With Bleeding Ulcers
Status:
Completed
Trial end date:
2007-12-01
Target enrollment:
Participant gender:
Summary
Patients with bleeding ulcers identified by endoscopy will be randomly assigned to receive an
acid-blocking drug (called a proton pump inhibitor [PPI]) either by mouth every 3 hours for
24 hours or intravenously (IV) by constant infusion for 24 hours. A pH probe in the stomach
will be used to determine intragastric pH (a measure of the acid production in the stomach)
at baseline and during the 24 hours of therapy. The purpose of the study is to determine if
the continuous intravenous administration of the drug provides better reduction of acid in
the stomach than the oral administration.