Trial of Lithium Carbonate for Treatment of Osteoporosis-pseudoglioma Syndrome
Status:
Completed
Trial end date:
2014-07-01
Target enrollment:
Participant gender:
Summary
This was a pilot study of 10 patients with Osteoporosis-pseudoglioma syndrome (OPPG) from the
Old Order Mennonite community and 16 controls, who did not have OPPG. Five of the 10 OPPG
patient elected to participate in the Lithium trial and 5 participated only in baseline data
(labs, pQCT). The 5 with OPPG who were given lithium for 6 months had both dual energy xray
absorptiometry (DXA), peripheral quantitative computerized tomography (pQCT) and lab
assessment at baseline and 6 months. Studies in the mouse model of OPPG showed that lithium
normalized their bone strength. Controls (n=16) were recruited from the Old Order Mennonite
community, to minimize the effects of environmental and lifestyle factors. The controls were
not be given lithium. The age range of participants was 4-64 years.
Phase:
N/A
Details
Lead Sponsor:
University of Maryland University of Maryland, Baltimore