Overview

Trial of Faropenem and Cefadroxil (in Combination With Amoxicillin/Clavulanic Acid and Standard TB Drugs) in Patients With Pulmonary Tuberculosis: Measurement of Early Bactericidal Activity and Effects on Novel Biomarkers

Status:
Completed

Trial end date:
2019-10-02

Target enrollment:

Participant gender:

Summary

This trial aims to determine whether the early bactericidal activity of rifampicin given with faropenem or cefadroxil (each given with amoxicillin/clavulanic acid) is greater than the activity of rifampicin alone in patients with pulmonary TB. The trial will also investigate potential new biomarkers of sterilising activity.

Phase:

Phase 2

Details

Lead Sponsor:

National University Hospital, Singapore

Treatments:

Amoxicillin
Amoxicillin-Potassium Clavulanate Combination
beta-Lactams
Cefadroxil
Clavulanic Acid
Clavulanic Acids
Isoniazid
Pyrazinamide
Rifampin