The Investigator has chosen to study the reconstructive spinal surgery patient population
because it is believed that the use of alvimopan in these patients at the University of
Virginia will give the scientific community significant insight into the broader
applicability of this drug into other surgical populations, the impact of this drug on the
perception of pain (as opposed to simply the consumption of opioids), and its impact on total
hospital charges, resource utilization, and functional outcomes.