Overview

Trial Comparing a Multi-Modal Pain Protocol With and Without Opioids Following Total Joint Arthroplasty

Status:
Completed
Trial end date:
2020-07-28
Target enrollment:
Participant gender:
Summary
To help curb the use of opioid medications following orthopedic surgery investigators have developed a new multi-modal pain pathway. Investigators aim to compare this regimen with and without the inclusion of opioid medications. This study will be performed in a randomized, double-blinded, placebo-controlled fashion in patients undergoing primary total knee or total hip arthroplasty. Investigators hypothesize that the opioid devoid pathway will show equivalent pain scores to the pathway that includes opioids while also having less constipation, nausea, and vomiting following surgery. If successful, this would create a dramatic decrease in opioid consumption following orthopedic surgery while still providing appropriate pain relief to patients.
Phase:
Early Phase 1
Details
Lead Sponsor:
Mayo Clinic
Collaborators:
Ambit Biosciences Corporation
Kern Medical Center
Treatments:
Analgesics, Opioid
Oxycodone