The study involves approximately 105 adolescent (ages 12-17) subjects to be screened at 4
sites across the US. All subjects enrolled will treat up to 4 MILD migraines over a 6 month
period. They will be required to have three office visits during the six months. All subjects
will be randomized to either Treximet (85mg Imitrex/500mg Naproxen Sodium) or Placebo
(sugar-pill) in four of the five treatment arms with a 3 to 1 ratio. A fifth treatment arm
will treat all 4 migraines with active drug, Treximet. The hypothesis is that Treximet will
prove to be a safe and effective treatment for this population, that has so few treatment for
migraine. And Treximet will be superior over placebo for pain free endpoints at 2 and 24
hours.