Treprostinil Iontophoresis : a Pharmacodynamic and Pharmacokinetic Study

• Status: Unknown status
• Trial end date: 2014-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of the study is to assess skin blood flow after non-invasive local administration of treprostinil by using a low-intensity current (i.e. iontophoresis) on the forearm and the fingers of healthy volunteers and patients with systemic sclerosis. The investigators also aim at assessing the systemic bioavailability and dermal diffusion of treprostinil iontophoresis.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University Hospital, Grenoble
• Treatments: Treprostinil

Criteria

Inclusion Criteria:

• Cutaneous systemic scleroderma with sclerosed fingers

Exclusion Criteria:

• pregnant or breast-feeding women

• any chronic disease (in the control group)

• smoking