Trem-1 and Ultraviolet Radiation-induced Immune Suppression

• Status: Not yet recruiting
• Trial end date: 2026-10-01
• Target enrollment: 0
• Participant gender: All

Summary

The overall goal of this study is to determine novel mechanisms for ultraviolet light (UV)-induced suppression of the immune system in human subjects and to improve understanding of UV-induced skin carcinogenesis.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Alabama at Birmingham

Criteria

• Inclusion Criteria

• Patient age 18-35

• Patient able to understand requirements of the study and risks involved

• Patient able to sign a consent form

Exclusion Criteria:

• Patients Fitzpatrick IV-VI

• A recent history of vitiligo, melasma, and other disorders of pigmentation with the exception of post inflammatory hyperpigmentation

• Patients with eczema, psoriasis, and contact dermatitis

• A known history of photosensitivity disorders

• A known history of melanoma or non-melanoma skin cancers

• Those planning on going to the tanning parlors

• Using any of the photosensitizing medication

• A woman who is lactating, pregnant, or planning to become pregnant

• Patient planning on exposing the irradiated or control areas to the sun

• Patients with organ transplantation, an immunodeficiency disorder or the use of an immunosuppressive drug