Overview

Treatment of Women After Severe Postpartum Haemorrhage

Status:
Completed
Trial end date:
2015-08-01
Target enrollment:
0
Participant gender:
Female
Summary
The primary purpose of this study is to get explorative information about IV high single dose infusion of iron isomaltoside 1000 compared to RBC transfusion in the treatment of severe PP-IDA evaluated as physical fatigue
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Pharmacosmos A/S
Collaborator:
BioStata
Treatments:
Ferric Compounds
Iron
Iron isomaltoside 1000
Criteria
Inclusion Criteria:

1. PPH > 1000 mL

2. Hb ≥ 5.5 and ≤ 8.0 g/dL (≥ 3.5 and ≤ 5.0 mmol/L)

3. Willingness to participate and signed the informed consent form

Exclusion Criteria:

1. Women aged < 18 years

2. Multiple births

3. Peripartum RBC transfusion

4. Known iron overload or disturbances in utilisation of iron (e.g. haemochromatosis and
haemosiderosis)

5. Known hypersensitivity to parenteral iron or any excipients in the investigational
drug products

6. Women with a history of active asthma within the last 5 years or a history of multiple
allergies

7. Known decompensated liver cirrhosis and active hepatitis

8. Women with HELLP (Haemolysis Elevated Liver enzymes Low Platelet count) syndrome
(defined according to "Dansk Selskab for Obstetrik og Gynækologi guidelines")

9. Active acute infection assessed by clinical judgement

10. Rheumatoid arthritis with symptoms or signs of active joint inflammation

11. History of anaemia caused by e. g. thalassemia, hypersplenism or haemolytic anaemia
(known haematologic disorder other than iron deficiency)

12. Not able to read, speak and understand the Danish language

13. Participation in any other clinical study where the study drug has not passed 5
half-lives prior to the baseline

14. Any other medical condition that, in the opinion of Investigator, may cause the
patient to be unsuitable for completion of the study or place the patient at potential
risk from being in the study. For example, a malignancy, uncontrolled hypertension,
unstable ischaemic heart disease or uncontrolled diabetes mellitus