Treatment of Post-Operative Sinonasal Polyposis With Topical Furosemide
Status:
Recruiting
Trial end date:
2024-06-01
Target enrollment:
Participant gender:
Summary
Prior studies have suggested that topical furosemide may reduce the recurrence of sinonasal
polyposis following sinus surgery. This project aims to further investigate that claim
through a blinded randomized controlled clinical trial following patients who undergo
functional sinus surgery for chronic rhinosinusitis with sinonasal polyposis by randomly
assigning participants to receive topical furosemide versus placebo nasal spray for 2 months
post operatively. Outcomes would be compared at 6 months through endoscopic grading scores
using Lund Kennedy and Meltzer scores as well as Sino-Nasal Outcome Test (SNOT-22) scores to
measure the rate and degree of recurrence and impact on symptoms in the treatment group
versus placebo.