Overview

Treatment of Poor Ovarian Responders With Corifollitropin Alfa Followed by hpHMG in a Short GnRH Agonist Protocol

Status:
Completed
Trial end date:
2013-05-01
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of the present study is to examine the level of ovarian response and the pregnancy rates among poor ovarian responders treated with a novel treatment protocol with 150μg corifollitropin alfa followed by 300IU hMG in a short GnRH agonist protocol.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Universitair Ziekenhuis Brussel
Treatments:
Deslorelin
Triptorelin Pamoate
Criteria
Inclusion Criteria:

Patients should fulfill the "Bologna criteria" for poor ovarian response

At least two of the following three features must be present:

i. Advanced maternal age (≥40 years) or any other risk factor for POR (poor ovarian
response); ii. A previous POR (≤3 oocytes with a conventional stimulation protocol); iii.
An abnormal ovarian reserve test (i.e. AFC <7 follicles or AMH <1.1 ng/ml).

Two episodes of POR after maximal stimulation are sufficient to define a patient as poor
responder in the absence of advanced maternal age or abnormal ORT (ovarian reserve test).

Exclusion Criteria:

-