Treatment of Patients With Idiopathic Membranous Nephropathy

• Status: Completed
• Trial end date: 2008-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Patients with idiopathic membranous nephropathy at risk for renal failure can be identified in an early stage by measuring urinary low molecular weight proteins and urinary immunoglobulin G (IgG). This study evaluates the possible benefit of early start of immunosuppressive therapy in these high-risk patients.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Radboud University
• Treatments: Cyclophosphamide; Prednisolone

Criteria

Inclusion Criteria:

• Idiopathic membranous nephropathy

• Serum creatinine < 1.5 mg/dl

• Nephrotic syndrome

Exclusion Criteria:

• Infection

• Instable angina

• Systemic disease

• Pregnancy

• Renal vein thrombosis

• Prior therapy with immunosuppressant agents

• Liver dysfunction

• Use of nonsteroidal anti-inflammatory drugs (NSAIDs)