Treatment of Orthostatic Intolerance

• Status: Active, not recruiting
• Trial end date: 2025-12-01

Summary

This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with this disorder.

• Phase: Phase 1/Phase 2

Details

• Lead Sponsor: Satish R. Raj
• Collaborator: National Institutes of Health (NIH)
• Treatments: Acetazolamide; Armodafinil; Atomoxetine Hydrochloride; Clonidine; Entacapone; Indomethacin; Isosorbide; Isosorbide Dinitrate; Isosorbide-5-mononitrate; Mecamylamine; Melatonin; Memantine; Midodrine; Modafinil; Octreotide; Propranolol; Sertraline