Overview

Treatment of Orthostatic Hypotension

Status:
Completed
Trial end date:
2020-12-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to try different medications in patients with low blood pressure and other problems with their involuntary (autonomic) nervous system. The pharmacological trials in this study will perhaps lead to more effective treatment. This study consists of single dose trials, dose selection trials, 5-day trials and chronic (approximately 2 months) trials.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Vanderbilt University
Vanderbilt University Medical Center
Treatments:
alpha-Methyltyrosine
Atomoxetine Hydrochloride
Carbidopa
Droxidopa
Levodopa
Methyldopa
Metoclopramide
Criteria
Inclusion Criteria:

- patients with severe orthostatic hypotension and other autonomic symptoms who do not
meet criteria for one of our standard diagnoses

- non-smokers

- drug-free

- able to give informed consent

- free of pulmonary, renal, hematopoietic, hepatic and cardiac disease

Exclusion Criteria:

- medications affecting the autonomic nervous system

- any chronic illness (cardiac, pulmonary, endocrine, gastrointestinal, rheumatologic)

- anemia (Hct < 30)

- women of childbearing age who are pregnant or nursing

- smokers