Treatment of Orthostatic Hypotension in SCI

• Status: Not yet recruiting
• Trial end date: 2026-06-30
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to identify the effects of non-pharmacological and pharmacological anti-hypotensive treatment interventions on orthostatic hemodynamic responses, symptoms of autonomic dysreflexia and orthostatic hypotension, and levels of fatigue and comfort in hypotensive individuals with SCI.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: James J. Peters Veterans Affairs Medical Center
• Collaborator: Kessler Foundation
• Treatments: Droxidopa; Midodrine

Criteria

Inclusion Criteria:

• traumatic spinal cord injury

• at least 12 months post injury

• injury level of C1-T6

• AIS A, B or C

• non-ambulatory

• non-ventilator

Exclusion Criteria:

• Active psychiatric disorder

• Stroke or cerebrovascular disease

• Alzheimer's Disease or dementia

• Unmanaged cardiac arrhythmias

• Concurrent systemic, hepatic, or renal disease

• Suspected or diagnosed malignancy

• Neurological disease other than SCI

• Self-reported history of three or more symptomatic episodes of AD per day