Treatment of Opioid/Heroin Dependence: Comparison of Three Medication Dosing Regimens

• Status: Completed
• Trial end date: 2005-07-01
• Target enrollment: 0
• Participant gender: All

Summary

Heroin dependence remains a major addiction problem in the United States. The purpose of this study is to determine the effectiveness of levoacetyl methadol (ORLAAM) in treating heroin dependent individuals.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA)
• Treatments: Methadyl Acetate

Criteria

Inclusion Criteria:

• Current opiate dependence

• Provides acceptable proof of identity

• History of 5 or more years of regular heroin use or dependence

• Reads and writes English

Exclusion Criteria:

• Significant suicidal or homicidal ideation, intent, or plan

• Current AXIS I psychotic, depressive, or anxiety disorder

• Meets DSM-IV criteria for dependence on any drug other than nicotine

• Impending legal complications or incarceration

• On parole or probation that requires reports of drug use or research data

• Currently receiving treatment for opiate dependence

• Currently participating in a 12-step substance detoxification program

• Medical condition that contraindicates administration of ORLAAM

• Plans to leave Houston, Texas within the year following study entry

• Pregnant or breastfeeding

• History of heart problems, including heart arrhythmias

• Requires psychotropic medications (e.g., antidepressants, antipsychotics, anxiolytics)