Treatment of Olfactory Dysfunction in Seasonal Allergic Rhinitis

• Status: Terminated
• Trial end date: 2008-09-01
• Target enrollment: 0
• Participant gender: All

Summary

People with allergies frequently complain of a loss or reduction in the sense of smell.

In this study, the investigators propose to perform a randomized, double blind, placebo controlled parallel study of subjects with nasal allergies and decreased smell to determine the effect of a treatment for allergies on the sense of smell.

• Phase: Phase 4
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Chicago
• Collaborator: Schering-Plough
• Treatments: Mometasone Furoate

Criteria

Inclusion Criteria:

1. Males and females between 18 and 59 years of age.

2. Seasonal allergic rhinitis by clinical history, with symptoms of impaired olfaction.

3. Positive skin or RAST test to allergen.

4. Symptoms of olfactory dysfunction.

5. No significant history of chronic sinusitis.

Exclusion Criteria:

1. Women of childbearing potential not using the contraception method(s) (Birth control pills, depo Provera, double barrier) as well as women who are breastfeeding.

2. Patients with severe medical condition(s) that in the view of the investigator prohibits participation in the study (heart, lung, kidney, neurological, oncologic or liver disease).

3. Use of any other investigational agent in the last 30 days.

4. Absence of olfactory or nasal symptoms.

5. Use of medications that may affect olfaction.

6. Medical conditions that may affect olfaction.

7. Smoking.

8. URI at the time of screening.