Overview

Treatment of Non-alcoholic Steatohepatitis (NASH) Patients With Vitamin D

Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
0
Participant gender:
All
Summary
Test the efficacy of vitamin D to improve non-alcoholic steatohepatitis with regard to biochemical and histological parameters. - Trial with medicinal product
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University of Zurich
Treatments:
Cholecalciferol
Ergocalciferols
Vitamin D
Vitamins
Criteria
Inclusion criteria:

- Patients with 25-OH vitamin D insufficiency

- Elevated alanine aminotransferase level

- Diagnosis of definite or possible steatohepatitis (NASH)

Exclusion criteria:

- Cirrhosis, present liver disease other than NASH

- Serious diseases limiting life expectancy,

- Breast-feeding or pregnant women

- Unhealthy alcohol consumption

- Drug abuse or substitution therapy

- Use of vitamin preparations within the previous 6 months and during the study

- Weight loss >5% within 12 months before study entry

- Newly diagnosed Diabetes mellitus requiring medical treatment within 12 months before
study entry

- Use of anti-obesity drugs

- Previous or current hypercalcemia

- Chronic renal disease