Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal gland. As humans grow
older the levels of DHEA naturally decrease. Low levels of DHEA have been associated with a
variety of harmful effects, including increased heart disease, decreased immune system
function, decreased bone density (osteoporosis), high cholesterol, and increased fat to
muscle ratio.
Blood levels of DHEA and its sulfate form, DHEA-S, begin dropping when humans are in their
20's. By the time humans are in their 40's and 50's, levels of DHEA and DHEA-S levels are at
50% of their peak. Previous studies have shown that levels of these hormones are associated
with feelings of "well-being" and enjoyment of "leisure" activities.
In this study researchers are interested in the effects on mood and behavior of DHEA in men
and women with mid-life related mood disorders. Specifically, researchers would like to find
out if increasing levels of DHEA will lessen the symptoms associated with these disorders.