Treatment of Metabolic Alkalosis in Acute Exacerbations of Cystic Fibrosis
Status:
Unknown status
Trial end date:
2006-02-01
Target enrollment:
Participant gender:
Summary
Adult cystic fibrosis (CF) patients admitted with an acute infection complicated by acid-base
disturbance and decreased ventilation will be studied.
They will receive salt replacement to correct the acid-base disturbance and possibly their
ventilation.
Assessment of symptoms (questionnaire), acid-base and electrolyte status (blood and urine
tests) ventilation (overnight oxygen and carbon dioxide monitoring non-invasively) and
sleep-wake pattern (actigraphy) will be carried out.
Study hypothesis: Acute volume and electrolyte replacement corrects hypochloremic hypovolemic
metabolic alkalosis and compensatory hypoventilation/ hypercapnia in acute exacerbations of
cystic fibrosis.
Phase:
Phase 2/Phase 3
Details
Lead Sponsor:
Bayside Health
Collaborators:
Cystic Fibrosis Federation Australia Monash University National Health and Medical Research Council, Australia