Treatment of Melasma With Stabilized Kligman Preparation Associated or Not With Pulsed Dye Laser
Status:
Terminated
Trial end date:
2010-12-01
Target enrollment:
Participant gender:
Summary
Melasma is an acquired disorder of pigmentation that leads to irregular pigmented patches on
the face. Treatment is difficult and to date the best treatment option is the combination of
hydroquinone, retinoic acid and steroids combined in topical daily application (called
Kligman's trio). Q-switched pigmentary lasers are usually ineffective and can induce post
inflammatory hyperpigmentation (PIH). Intense pulsed light can sometimes improve melasma but
also induce PIH which limit their use. Recently, pulsed dye laser were demonstrated to be
effective in treating some pigmentary defects. Associating blanching cream with hydroquinone
to prevent PIH after laser or intense pulsed light has been already reported with success.
The objective of the study is to compare in a prospective intra individual comparative trial
the association of pulsed dye laser plus stabilized Kligman's trio to Kligman's trio alone.
The secondary objective was to study the frequency and the intensity of the potential side
effects including PIH.