Treatment of Macroglobulinemic Lymphoma With 2CdA, Cyclophosphamide and Rituximab
Status:
Active, not recruiting
Trial end date:
2020-07-31
Target enrollment:
Participant gender:
Summary
The goal of this clinical research study is to see how well the drugs 2CdA, cyclophosphamide,
and rituximab (rituxan) shrink a lymphoma called Waldenstrom's macroglobulinemia. After these
drugs are given for 2 courses, a second goal is to see how long a remission lasts. A third
goal is to see how often repeat remissions can be achieved when the lymphoma returns later
and the same drugs are restarted.
This is an investigational study. The FDA has approved each of these drugs for the treatment
of low-grade lymphoma. The combined use of these drugs for Waldenstrom's macroglobulinemia is
investigational, although each drug has been effective by itself for this disease. About 50
patients will take part in this study. This study will take place only at UTMDACC (outpatient
basis).