Treatment of Liver Cirrhosis Due to Hepatitis B Virus With Fuzheng Huayu and Entecavir
Status:
Unknown status
Trial end date:
2019-06-01
Target enrollment:
Participant gender:
Summary
Liver Cirrhosis is a common pathological consequence of chronic liver disease. Hepatitis B
Virus (HBV) is one of most etiologies of liver cirrhosis in China. The effective inhibition
of HBV can partially stop or reverse liver fibrosis in patients with chronic Hepatitis and
liver cirrhosis due to HBV, and the anti-fibrotic strategy focusing on the regulation of
hepatic extracellular matrix is still required and hopefully improve the efficacy of
anti-virals for liver fibrotic patients with HBV, especially is necessary for in the patients
with advance fibrosis stage ie. liver cirrhosis. Fuzheng Huayu has been found to enhance the
degradation of collagens in fibrotic liver and have a good action against liver fibrosis in
patients with chronic hepatitis B. However, there are no high quality clinical evidences
which can demonstrate if the combination of anti-viral and anti-fibrotic therapy can improve
the reversion of liver cirrhosis due to HBV.
The primary objective of this study is to establish the safety and efficacy of the
combination of Entecavir and Fuzheng Huayu for the reversion of liver fibrosis in patients
with liver cirrhosis due to HBV.
Phase:
Phase 4
Details
Lead Sponsor:
ShuGuang Hospital
Collaborators:
Affiliated Hospital of Shandong Univercity of TCM Beijing Ditan Hospital Beijing YouAn Hospital China-Japan Friendship Hospital Fifth Hospital of Shijiazhuang City Guang'anmen Hospital of China Academy of Chinese Medical Sciences Guangxi Ruikang Hospital Huai'an No. 4 People's Hospital Hubei Hospital of Traditional Chinese Medicine Jingmen No.1 People's Hospital Jingmen No.1 People’s Hospital Ruijin Hospital Shandong University of Traditional Chinese Medicine Shanghai Zhongshan Hospital Shenzhen Third People's Hospital The Fifth People's Hospital of Anyang The Fifth People's Hospital of Suzhou The Fifth People’s Hospital of Anyang The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine The Ninth Hospital of Nanchang The People's Hospital of Ningxia Tongji Hospital Wenzhou Central Hospital