Treatment of Intrauterine Adhesions and Its Distribution of Genital Tract Flora

• Status: Recruiting
• Trial end date: 2021-12-31
• Target enrollment: 0
• Participant gender: Female

Summary

This study aims to investigate the treatment of intrauterine adhesion and the factors influencing its prognosis.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: First Affiliated Hospital, Sun Yat-Sen University

Criteria

Inclusion Criteria:

Inclusion Criteria(experimental group and control group):

• Pre-operative adhesion score was ≥5

• The prior menstrual cycle was regular, and the sex hormone was normal

• Patients had fertility requirement

• Male semen examination showed normal

• There were no severe systemic diseases, and no contradictions to aspirin, estrogen and surgery

Inclusion Criteria(healthy control group):

• regular menstrual cycles,diagnostic hysteroscopy with endometrial biopsy and laparoscopy as part of their infertility diagnostic work-up prior to IVF, hysteroscopy and subsequent pathological results having shown no abnormality in the uterine cavities and abdominal cavity

• the healthy women recruited had male partners who were infertile and diagnosed with defective sperm function,such as asthenozoospermia, oligoasthenozoospermia, severe oligoasthenozoospermia and azoospermia, defined according to guidelines published by the World Health Organization.

Exclusion Criteria:

• Pre-operative adhesion score was <5

• Prior menstrual cycle was irregular and sex hormone was abnormal, or patients had endocrine factors that caused amenorrhea, menstrual reduction and infertility

• Patients had no fertility requirement

• Patients(experimental group and control group) had male factor infertility

• Patients had contradictions to estrogen and aspirin such as cancers (breast cancer and endometrial cancer), thrombotic diseases, allergy to antipyretic analgesics, severe liver injury, hypoprothrombinemia, vitamin K deficiency, hemophilia, thrombocytopenia, gastric or duodenal ulcer and asthma.

• refuse Endometrial biopsy

• Vaginal discharge abnormal, or suspected vaginitis or pelvic inflammatory disease, or using antibiotics.