Treatment of IgAN With Multi-glycoside of Tripterygium Wilfordii HOOK. f.

• Status: Unknown status
• Trial end date: 2015-09-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine whether Multi-glycoside of Tripterygium Wilfordii HOOK. f. is effective and safe in the treatment of IgA nephropathy.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Second Xiangya Hospital of Central South University
• Treatments: Cardiac Glycosides; Mycophenolate mofetil; Mycophenolic Acid

Criteria

Inclusion Criteria:

• urinary protein levels ≥1.0 g/24 h

• estimated glomerular filtration rate (eGFR) ≥30 ml·min-1·1.73 m-2body surface area by the MDRD formula (eGFR=194×age-0.287×serum creatinine

• 1.094(×0.739, if female) (where sCr is the serum creatinine, dry chemistry method, mg/dl))

• peripheral blood white blood cell count ≥3000×109/L

• no other cause for tubulointerstitial lesions

• no history of immunomodulatory agent intake before renal biopsy

• no systemic infection

• age between 16 and 65 years

Exclusion Criteria:

• severe infections