Treatment of Hypoglycemia Following Gastric Bypass Surgery
Status:
Completed
Trial end date:
2017-04-08
Target enrollment:
Participant gender:
Summary
Obesity is increasing worldwide and consequently the need for efficient treatment
opportunities. Roux-en-Y gastric bypass (RYGB) is one of the most commonly performed
bariatric procedures used in the treatment of severe obesity. The surgery results in
significant and sustained weight loss and has a beneficial effect on blood glucose
regulation.
However, some patients experience the syndrome postprandial hyperinsulinemic hypoglycemia
years after the operation, with symptoms varying from mild dizziness to confusion, loss of
consciousness and seizures. Larger insulin and glucagon-like peptide 1 (GLP-1) responses to
an oral glucose load are believed to play a role in the syndrome, which is not yet fully
understood. There are no current treatment guidelines beside dietary recommendations.
The purpose of this study is to compare different pharmacological treatments on daily blood
glucose variations as well as postprandial hormonal and autonomous changes in subjects with
symptoms of postprandial hyperinsulinemic hypoglycemia after RYGB.