Treatment of Hyperglycaemia and Insulin Resistance in HIV Infected Patients

• Status: Completed
• Trial end date: 1969-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

The purpose of this study is to evaluate and compare the effects of treatment with rosiglitazone and metformin on insulin resistance in patients infected with Human Immunodeficiency Virus on stable Highly Active Antiretroviral Therapy including a Protease Inhibitor after the period of 48 weeks.

• Phase: N/A

Details

• Lead Sponsor: University Medical Centre Ljubljana
• Treatments: Metformin; Rosiglitazone

Criteria

Inclusion Criteria:

• documented HIV infection

• stable Protease Inhibitor containing HAART regimen for at least 12 months

• impaired glucose tolerance

• elevated insulin levels (above 20 mIU/l)

Exclusion Criteria:

• patients already taking oral hypoglycaemic treatment or insulin

• heart failure NYHA I-IV

• liver disease or kidney disease

• elevated AST or ALT above 2 times upper normal range

• elevated creatinine (above 150 mmol/l)