Treatment of Early RA: Minocycline in Combination With Methotrexate vs Methotrexate Alone

• Status: Completed
• Trial end date: 2006-05-31
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to determine if a combination of methotrexate and minocycline works better than methotrexate alone in early Rheumatoid Arthritis

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Nebraska
• Treatments: Methotrexate; Minocycline; Prednisone

Criteria

Inclusion Criteria:

• Age over or equal to 19 years old and less than or equal to 75 years old

• Diagnosis of RA as determined by fulfilling 4 of 7 ACR criteria

• Positive rheumatoid factor

• Duration of disease: greater than six weeks and less than one year

Exclusion Criteria:

• Allergy to tetracycline or methotrexate

• Previous DMARD treatment

• Doses of oral steroids greater than 7.5 mg/day

• Intra-articular injections within the last four weeks

• Significant liver or renal disease or active peptic ulcer disease

• Patients who are not willing to abstain from alcohol consumption

• Women of childbearing potential who are not practicing a successful method of contraception