Treatment of Early Knee Osteoarthritis With Autologous Adipose-derived Mesenchymal Stem Cells

• Status: Active, not recruiting
• Trial end date: 2020-11-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to explore the efficacy and safety of autologous adipose mesenchymal stem cells in the treatment of early knee arthritis. Investigator believes that autologous adipose mesenchymal stem cells can relieve pain, improve knee function, promote knee cartilage regeneration and improve life satisfaction of patients.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Qilu Hospital of Shandong University

Criteria

Inclusion Criteria:

• Aged 18-65 years, male and female, patient can tolerate surgery;

• Clinical diagnosis of early stage degenerative arthritis by Radiographic Criteria and physical examination;

• Obviously extra-articular malformation;

• Course of disease ≥ six months;

• No medication for knee osteoarthritis in the past three months

• Evaluated has not at the risk of cancer;

• Subjects who understand and sign the consent form for this study.

Exclusion Criteria:

• Acute joint injury;

• Patients with severe primary diseases, such as cardiovascular,cerebrovascular, liver, kidney and hematopoietic system, and psychosis;

• Cancer patients;

• Women who are pregnant or breast feeding,or allergic constitution patient;

• Positive serology for HIV-1 or HIV-2, Hepatitis B (HBsAg, Anti-Hepatitis C virus -Ab), Hepatitis C (Anti-hepatitis C virus -Ab) and syphilis;

• Receive other open surgery related to knee operation within 6 months;

• Participation in another clinical trial;

• Failing to comply with the inclusion criteria, unwilling to comply with the research approach, or incomplete data affecting the curative effect or safety judgment.