Treatment of Dysglycemia Using Sitagliptin in Adolescents With Cystic Fibrosis
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
This pilot study will be conducted in adolescents with cystic fibrosis (CF) without diabetes
but with abnormal glucose tolerance, and will assess the effects of sitagliptin on glucose
regulation. An oral glucose tolerance test (OGTT) and a mixed meal tolerance test (MMTT),
will be performed at baseline and again ~4 weeks after treatment with study drug. We will
also look at blood sugars throughout the day using a continuous glucose monitor (CGM) before
each time the MMTT/OGTT are performed. Several hormones that may affect the way the body
regulates blood sugars will be measured in blood when the OGTT and MMTT are done. We will
assess the effect this medicine has on blood sugars (using CGM) and the effect the medicine
has on the hormones measured during the OGTT and MMTT.