Treatment of Dry Eye Using 0.03% Tacrolimus Eye Drops
Status:
Completed
Trial end date:
2011-11-01
Target enrollment:
Participant gender:
Summary
Aqueous deficiency dry eye is mainly caused by Sjogren syndrome (SS), an autoimmune, chronic,
inflammatory and systemic disease which affects most commonly the lacrimal and salivary
glands.The ocular treatment is focused in increasing lubrification and decreasing
inflammation with topical autologous serum, topical immunosuppressive agents and
corticotherapy. Use of topical immunosuppressants has increased in recent years because the
topical corticotherapy leads to ocular complications. The most used immunosuppressant is
cyclosporine. Tacrolimus , another immunosuppressant, has been used in treatment of immune
and inflammatory ocular diseases.This study describes a prospective controlled double-blinded
randomized study of the clinical outcome of SS dry eyes patients treated with 0.03%
tacrolimus eye drops. As secondary purposes, outcome of dry eye symptoms and any ocular
symptoms of the eye drops were also questioned to the patients.