Treatment of Depression Following Multiple Brain Tests

• Status: Completed
• Trial end date: 2007-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The main purpose of this study is to correlate brain testing with treatment outcome.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: New York State Psychiatric Institute
• Treatments: Bupropion; Citalopram; Dexetimide; Imipramine

Criteria

Inclusion Criteria:

• DSM-IV Major Depression or Dysthymia

• Age 18-65

• Physically healthy

• Normal hearing

• Drug-free (two weeks for most antidepressants, four weeks for Fluoxetine)

Exclusion Criteria:

• Hearing deficit in one or both ears

• Body metal (e.g., wire stitches, screws in bones, stainless steel hips)

• History of Psychosis or Epilepsy

• Current (past six months) Substance Use Disorder (illicit drugs and/or alcohol)

• Unstable medical problem

• Insufficient English for neuropsychological and dichotic testing

• Bipolar I

• Need for wash-out from effective treatment in order to participate

• Pregnant

• High suicide risk

• Currently taking (within 2 weeks; 4 weeks for Fluoxetine) antidepressants