Treatment of Cocaine Dependence: Comparison of Three Doses of Dextro-Amphetamine Sulfate and Placebo

• Status: Completed
• Trial end date: 2007-11-01
• Target enrollment: 0
• Participant gender: All

Summary

Dextro-amphetamine sulfate is a central nervous system stimulant that increases the release of the neurotransmitter dopamine in the brain. The purpose of this study is to further examine dose ranges of dextro-amphetamine sulfate as a treatment for cocaine dependence.

• Phase: Phase 2
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: National Institute on Drug Abuse (NIDA); The University of Texas Health Science Center, Houston
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Amphetamine; Cocaine; Dextroamphetamine

Criteria

Inclusion Criteria:

• DSM-IV diagnosis of cocaine dependence, as determined by the Structured Clinical Interview for DSM-IV

• Agreement to use an adequate method of contraception for the duration of the study

• Electrocardiogram confirmation by a cardiologist

• Cocaine-positive urine test prior to study entry

Exclusion Criteria:

• High blood pressure

• Significant heart disease

• Clinically significant cardiovascular abnormality

• Angina

• Kidney, liver, or gastrointestinal disorder

• Current Axis I disorder not related to drug use

• Current dependence on any drug other than nicotine

• Attention deficit disorder (ADD) or attention deficit hyperactivity disorder (ADHD)

• On probation or parole for reasons other than those related to drug abuse charges

• Pregnant or breastfeeding

• Sought treatment for drug dependence within 3 months prior to study entry

• Currently taking prescribed medications