Treatment of Chronic Cryptosporidiosis in AIDS Patients
Status:
Terminated
Trial end date:
2005-06-01
Target enrollment:
Participant gender:
Summary
The purpose of this study is to see if it is safe and effective to add interleukin-12 (IL-12)
to the standard drug combination (paromomycin plus azithromycin) used to treat
cryptosporidiosis in AIDS patients. Doctors would like to find out if the combination of
IL-12, paromomycin, and azithromycin is more effective than paromomycin and azithromycin
alone.
Cryptosporidiosis is a type of opportunistic (AIDS-related) infection seen in HIV-positive
patients as their immune systems weaken. It is caused by a parasite that invades the
intestinal tract, and it can cause watery diarrhea, stomach cramps, an upset stomach, or a
fever. Antibiotics (paromomycin and azithromycin) are usually used to treat
cryptosporidiosis. In this study, doctors will look at the effectiveness of using IL-12.
IL-12 is a type of protein naturally produced by certain types of cells of the immune system
and is believed to be important for immune function. Doctors hope that IL-12 can help boost
the immune system in fighting cryptosporidiosis.
Phase:
N/A
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)