Treatment of Chemotherapy-related Hiccups With Baclofen
Status:
Unknown status
Trial end date:
2019-12-20
Target enrollment:
Participant gender:
Summary
Hiccup is one of the common side effects of chemotherapy. Intractable hiccups seriously
affect patients' rest and eating, reduce the quality of life, and increasingly attract the
attention of oncologists. At present, drugs or methods for treating chemotherapy-related
hiccups are generally ineffective, with short remission time, serious adverse reactions, and
unsatisfactory clinical effects. Baclofen produces skeletal muscle relaxation and was
originally used in patients with spinal cord injury, and has since been used to treat
intractable hiccups caused by diaphragmatic spasm. This study was an open-label, randomized,
prospective study comparing the efficacy and adverse effects of baclofen versus
metoclopramide in the treatment of chemotherapy-related hiccups. Patients with hiccup after
chemotherapy were randomly divided into two groups. One group was treated with baclofen and
the other group was treated with metoclopramide. The efficacy and adverse reactions of the
two groups were compared.Ineffective in the two groups will cross to another group and then
observe the efficacy.