Overview

Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor Zanubrutinib

Status:
Not yet recruiting
Trial end date:
2023-12-30
Target enrollment:
0
Participant gender:
All
Summary
Study consists of a single arm to explore the efficacy and safery of zanubrutinib in patients with CD79B mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
BeiGene
Treatments:
Zanubrutinib
Criteria
Inclusion Criteria:

1. Histologically confirmed DLBCL based on the World Health Organization (WHO) 2008
classification of tumors of hematopoietic and lymphoid tissue.

2. Positive CD79B mutation confirmed by the central laboratory.

3. Previously received at least 1 line of adequate systemic anti-DLBCL therapy, defined
as an anti-CD20 antibody-based chemoimmunotherapy for at least 2 consecutive cycles,
unless patients had disease progression before Cycle 2

4. Relapsed or refractory (R/R) disease before study entry, defined as either

1. Recurrent disease after having achieved disease remission (CR or partial response
[PR]) at the completion of the latest treatment regimen.

2. Stable disease or PD at the completion of the latest treatment regimen

5. Ineligible for high dose therapy/stem cell transplantation, which is defined as
meeting any of the following criteria:

1. Significant organ dysfunction (eg, left ventricular ejection fraction < 50% by
echocardiogram or multiple gated acquisition scan [MUGA], diffuse lung capacity
for carbon monoxide < 60% predicted by pulmonary function test, creatinine
clearance < 70 mL/min shown by nuclear medicine scan or 24-hour urine collection)
or comorbidities precluding the use of high dose therapy/stem cell
transplantation on the basis of unacceptable risk of treatment-related morbidity

2. Failure to achieve CR or PR with salvage therapy.

3. Failure to collect stem cells or unable to perform stem cell collection as
assessed by the investigator.

Exclusion Criteria:

1. Patients who have NHL other than classical histology DLBCL, eg, patients with DLBCL
transformed from indolent lymphomas, primary mediastinal (thymic) large B-cell
lymphoma, primary cutaneous DLBCL, primary effusion lymphoma, and central nervous
system (CNS) lymphoma.

2. History of allogeneic stem cell transplantation or chimeric antigen receptor (CAR)
T-cell therapy.

3. Prior exposure to a BTK inhibitor.

4. Receipt of the following treatment at the time indicated before the first dose of
study drug:

1. Corticosteroids given with antineoplastic intent more than 7 days, unless it is
for control of lymphoma-related symptoms provided it is tapered off within 5 days
after initiation of study treatment.

2. Chemotherapy or radiotherapy within 2 weeks.

3. Monoclonal antibody within 2 weeks.

4. Investigational therapy within 2 weeks.

5. Chinese patent medicine with antineoplastic intent within 2 weeks.

5. History of other active malignancies within 2 years before study entry, with the
exception of (1) adequately treated in-situ carcinoma of the cervix; (2) localized
basal cell or squamous cell carcinoma of the skin; (3) previous malignancy confined
and treated locally (surgery or other modality) with curative intent. Note: Other
protocol defined Inclusion/Exclusion criteria may apply.