Treatment of Bacterial Vaginosis Prior to Active Labor and Infectious Morbidity

• Status: Recruiting
• Trial end date: 2022-08-31
• Target enrollment: 0
• Participant gender: Female

Summary

Bacterial vaginosis (BV) is the most common cause of vaginal discharge among repro-ductive aged women. It is been linked to adverse maternal and neonatal outcomes. Our objective is to evaluate if the use of a single dose of metronidazole in women with BV at time of delivery reduces infectious morbidities

• Phase: Phase 1
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: The University of Texas Medical Branch, Galveston
• Treatments: Metronidazole

Criteria

Inclusion Criteria:

• Women ≤50 years at the time of admission with the ability to give informed con-sent.

• Admission for induction of labor or early spontaneous labor with cervix ≤3 cm.

• Diagnosed with bacterial vaginosis at time of admission or in the week prior to admission if not treated

• Gestational age ≥ 34 weeks

Exclusion Criteria:

• Spontaneous rupture of membranes

• Plan for elective cesarean delivery

• Allergy or contraindications to metronidazole

• Receipt of metronidazole or clindamycin in the admission for delivery for other in-dications.

• Hemodialysis

• Severe liver dysfunction

• Diagnosis of chorioamnionitis at the time of admission