Neutrophil elastase (NE) released by neutrophils play an important role in inflammatory
cascade and lung tissue injury of ARDS.Inhibition of NE is expected to prevent the
pathophysiological process of ARDS and alleviate lung injury. Siverestat sodium is a specific
inhibitor of NE, which has been proved by basic and observational clinical studies to be
effective in alleviating lung injury of ARDS, but there is a lack of prospective multi-center
randomized controlled clinical trials.Therefore, this study was intended to evaluate the
efficacy of sivelestat sodium in the treatment of ARDS patients with SIRS in a multicenter
randomized controlled clinical trial